![]() ![]() ![]() However, imaging with OctreoScan is time-intensive as it takes place 4, 24, and up to 48 hours after tracer injection. 4 OctreoScan is specific for SSTR2 and SSTR5, and provides enhanced precision in identifying tumors when employed with single-photon emission computed tomography (SPECT). Historically in this setting, scintigraphy using Indium (In) 111 pentetreotide (more commonly known by its trade name, OctreoScan) was applied. Five types of SSTRs have been identified on NETs with type 2 (SSTR2) being the most commonly overexpressed. 4 The mechanism of this type of imaging involves the binding of a radiolabeled somatostatin analog to SSTRs on tumor cells. 4,5 As such, SSTR-based radionuclide imaging (largely, SSTR positron emission tomography, which is usually combined with computerized tomography ) has emerged as the preferred imaging technique for identifying NETs. Somatostatin receptors (SSTRs) are typically overexpressed by NETs in a pattern related to tumor type, origin, and grade of differentiation. 4 However, because NETs are often are small and indolent in nature, they are difficult to identify even with sophisticated imaging modalities. 2,3Īccurate detection of NETs is crucial for directing patient management. Although the prevalence of NETs is low, the incidence of this malignancy in the United States has been steadily increasing and currently estimated at 8,000 cases annually. 1 More than half of these tumors originate from the gastrointestinal tract, mainly the small intestine and rectum, and about a quarter are pulmonary in origin. Neuroendocrine tumors (NETs) are rare tumors that develop in certain hormone-producing cells of the body’s neuroendocrine system. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |